Wednesday, December 25, 2019

Things You Should Know About Persuasive Research Essay Topics

Things You Should Know About Persuasive Research Essay Topics Thus, make certain there is sufficient research available. 1 important and appropriate subject is technology. You will be assigned a topic, or your professor will allow you to select your own. It's possible to select an intriguing topic from any area of science. Persuasive or argumentative essays are intended to convince the audience of ones viewpoint about a specific topic. Argumentative essay topics are so important since they are debatableand it's essential to at all times be critically contemplating the world around us. The procedure for getting good argumentative research essay topics is not simple. Persuasive papers (also referred to as argumentative essays) are possibly the most important academic projects you'll learn how to write. There are just a few things that define whether an essay you're working on is going to be a good one. Therefore, you can ask all the essential questions and consult on some points. Still, figuring out the very best topic for your essay isn't your only concern for a student. Put simply, you will need to attempt to comprehend where they're coming from. The Persuasive Research Essay Topics Chronicles Our seasoned persuasive paper writers will supply you with effective solutions to ordinary problems, even supposing it is an argumentative essay. Writing on persuasive research papers should also indicate that you are going to be willing and prepared to learn something new in regards to the topic. Argumentative research paper topics are a ton a lot easier to find than to produce. Argumentative writings is a particular kind of a paper. It's important to understand that essay topics are just basic ideas that leave you pondering a notion that might be a huge deal to somebody else. T he simplest way to pick a persuasive essay topic is to go over a present issue. Deciding on a persuasive essay topic may take a great deal of time without ending up with the terrific solution. Deciding on the proper topic for a persuasive speech can be not such an easy issue to do as it might appear. To choose which subject you're likely to discuss, it's crucial to see the complete collection of good persuasive speech topics from the specific area of study. Superficial or too wide research never creates a suitable impression. Usually, students are given the subject in the shape of a question so it's essential that the topic is crafted in a manner that reflects the A level essay question and therefore the thesis statement. Another reason is to observe how well students argue on unique views and demonstrate understanding of the studied subject. Quite frequently, the ideal topic is one which you truly care about, but you also will need to get well prepared to research it. Pickin g an effortless topic may prove to be an incorrect track because you may have difficulties finding credible sources to support your views. Deciding on an emotional topic is also a superb idea. Discover which of the topics, you presently have a fairly good background on which will make it possible for you to have a relative edge. There are a great deal of great persuasive essay topics to pick from. You may also come up with all these topics prior to making a last selection on the topic that is most appropriate for you. There are many intriguing topics that could be become a persuasive essay if you take the opportunity to consider about doing it. Before you commence working on the paper, you must go through several topics to compose a persuasive essay on. Young writers may try simple on-line citation generators which are normally at no cost. You may buy argumentative essay from a specialist writer. You may continue to keep your argumentative essays for your upcoming job portfolio in case they're highly graded. Moral argumentative essay topics are a few of the simplest to get carried away with. Persuasive essays share a good deal of resemblance with argumentative essays. All persuasive essays are like argumentative essays. An argumentative essay is a certain sort of academic writing.

Tuesday, December 17, 2019

Character Analysis of Captain Beatty (Fahrenheit 451)

Beatty, the Nearly Enlightened As fire captain, it is Captain Beatty’s job to promote and direct the eradication of knowledge and free thought within his district through the burning of books in Ray Bradbury’s novel Fahrenheit 451. Though one may expect his job to be one occupied by a brutish, obtuse man with a powerful inferiority complex, this is not so: Beatty is obviously intelligent, well-versed in literature, but also completely devoted to the act of book-burning and the structure that supports it. He is more than just than an ardent rule follower, however; his own embarkation upon an academic quest soured and embittered him on literature. He unleashes his own burning anger against books and eventually Guy Montag, an†¦show more content†¦Also, as a precursor to Beatty’s increasing suspicions of Montag (and as Montag’s mind becomes increasingly unsettled with its current state of affairs) the Mechanical Hound becomes more aggressive toward Montag, signifying a realization of Beatty’s suspicions and allowing him to subvert Montag’s security about his secrecy. Bradbury hints at Beatty’s clever deduction of Montag’s activities by sending the Hound (in a wonderfully subtle, sly move) to literally â€Å"sniff around† Montag’s house: â€Å"Under the door, a slow, probing sniff, an exhalation of electric steam. [†¦] And the smell of blue electricity blowing under the locked door† (72). While the fear of the Hound does not abolish Montag’s resolve to read the books, it does weaken it and he hastens to finish his scholarly task because he is afraid he’ll be stopped. This is one of the few instances where Beatty does not attempt to sway Montag by outmaneuvering him in a debate but is still present for (in some form) and aware of an act that goes against both the law and the firemen’s code. The final act of Montag’s that Beatty is explicitly aware of and violates both the law and the firemen’s code is his murder. In a deed of fear, desperation, and (ironically) atonement, Montag burned him with his own flames; the force of destruction Beatty had released inside of each of his firemenShow MoreRelatedCharacterization Of A Hero In Ray Bradburys Fahrenheit 4511272 Words   |  6 Pagescharacterization of a hero is also true in Ray Bradburys novel, Fahrenheit 451. Rodney A. Smolla introduces the main character in â€Å"The Life of The Mind and A Life of Meaning: Reflections on Fahrenheit 451† stating that â€Å"Montag begins the novel ostensibly proud of his profession and settled in life, but we soon find that there is disquiet beneath the surface† (897). Throughout the continuation of the story, Guy Montag is the main character who ultimately refuses to be controlled by the dictated environmentRead MoreAnalysis of Metaphors and Symbols in Fahre nheit 4512249 Words   |  9 PagesFarris 3 Lauren Farris Mrs. Reid AP English 4 21 March 2006 Analysis of Metaphors and Symbols in Fahrenheit 451 Fahrenheit 451, by Ray Bradbury takes the reader to a time where firemen do not put out fires; they start them in order to burn books, because books and intelligent thinking is outlawed. By using a combination of metaphors and symbols in this novel, Bradbury deepens the intricacy of his central them that censorship and too much government control is dangerous, and men should beRead MoreRay Bradbury s Fahrenheit 4512496 Words   |  10 Pagesessay. Ray Bradbury’s novel Fahrenheit 451 uses different literary elements, and character is one of the most important elements that contributes to the richness of this novel. Bradbury takes readers into a far future to give them a hint of what their world may become if care is not taken. With the use of different elements, Bradbury builds a world like no other, setting the novel very far into the future, many generations after the novel is written. The use of characters accurately depicts the storyRead MoreFahrenheit 451 By Ray Bradbury2 826 Words   |  12 Pagesentitled Fahrenheit 451. Bradbury depicts a dystopian society filled with mechanic-like, mindless, and thoughtless individuals living a life they think is normal and comfortable, but to people of intelligence, people with an interest in freedom of thoughts and mental stimulation, this society seems controlled, close-minded and wrong. Fahrenheit 451 is a creative, thought provoking piece of literature that encompasses a futuristic society in which books are illegal and banned. Through an analysis of theRead MoreAnalysis Of Ray Bradbury s Fahrenheit 4511743 Words   |  7 PagesIn Fahrenheit 451, by Ray Bradbury, the protagonist, Guy Montag, suddenly realizes his overwhelming discontent with life when he meets Clarisse McClean, a seventeen year old girl who introduces him to beauty of the world and the notion of questioning ones surroundings. This novel, having been released shortly after the Second Read Scare, a time when fear of communism lead to the baseless accusation of political figures by Senator McCarthy, was received with mixed reviews. However, today more so thanRead MoreAnalysis Of Ray Bradbury s Fahrenheit 451 Essay2089 Words   |  9 PagesThe analysis of Ray Bradbury s dystopian novel, Fahrenheit 451, shows that literature as books, education and alike is abused and criminalized in the heroâ€℠¢s reality, who is Guy Montag. The novel’s setting is when new things seem to have totally replaced literature, fire fighters set flames instead of putting them out, the ownership of books is deserving of the law and to restrict the standard is to court demise. The oppression of literature through innovation and technology can be analyzed throughRead MoreA Comparative Analysis Of Bradbury s Style1974 Words   |  8 Pages28, 2015 A Comparative Analysis of Bradbury’s Style As Seen in Something Wicked This Way Comes and Fahrenheit 451 Ray Bradbury was an American author who many argue revolutionized the concept of science fiction writing. Many SF writers commend technology, yet Bradbury is quick to vocalize the danger of it. He is not afraid of conforming to the regular standards of science fiction and is not afraid to voice his thoughts about technology. The story of Fahrenheit 451 is a dystopian novel whereRead MoreCharacter Analysis of Guy Montag829 Words   |  4 PagesJohntay Fuller Ms. Fleming amp; Ms. Humes English November 20, 2012 Character analysis of Guy Montag â€Å"If they give you ruled paper, write the other way.† This quote by Juan Ramon Jimenez means that sometimes rules are meant to be broken and sometimes rules are not always for the betterment of society. Rules give us structure, but they can hinder our humanity towards one another. The book Fahrenheit 451 by Ray Bradbury is about a dystopian society where books are burned and outlawed. Guy MontagRead MoreThe Book of English2652 Words   |  11 PagesElena Moya Mrs. Fayter English 10 Honors January 16, 2011 Montag Fahrenheit 451 by Ray Bradbury Physical Charcoal hair soft-colored brows and blush ash smeared checks, an unshaven look Looks like all the other fire fighters Emotional At the beginning Montag was content and satisfied with his job and life After meeting Clarisse he became confused Admitted he is unhappy He feels a deep sense of guilt and pain because of the condition of society Intellectual It was Montag curiosityRead More Analysis of Fahrenheit 451 by Ray Bradbury Essay3557 Words   |  15 PagesAnalysis of Fahrenheit 451 by Ray Bradbury Imagine living in a world where you are not in control of your own thoughts. Imagine living in a world in which all the great thinkers of the past have been blurred from existence. Imagine living in a world where life no longer involves beauty, but instead a controlled system that the government is capable of manipulating. In Ray Bradburys Fahrenheit 451, such a world is brought to the awareness of the reader through a description of the impacts

Monday, December 9, 2019

Biomedical Science Tissue-resident Macrophages.

Question: Discuss about the Biomedical Science for Tissue-resident Macrophages. Answer: Introduction Macrophages are professional phagocytes. They are tissue resident and originate from monocytes, which are produced by the stem cells in the bone marrow (Epelman et al. 2014). Monocytes usually move out of the blood capillaries through the endothelium, by the process of diapedesis or leukocyte extravasations in response to infection or tissue damage. It then goes through a sequence of changes, to form a macrophage. The movement of monocytes towards a site of infection or damage is initiated by release of chemical substances at the site, which attracts the monocytes through chemotaxis. Definition Macrophages is a phagocytic tissue cell of the invulnerable framework that might be altered or unreservedly motile, is derived from a monocytes, capacities in the decimation of outside antigens (as microscopic organisms and infections), and serves as an Antigen Presenting Cells. In short they are big eaters. (Greek word: makros- Large + phagein- eat). Functions They play an important role in both adaptive and innate immunity. They are extensive, biosynthetically dynamic cells with intense endocytic, phagocytic, and secretory capacities, ready to balance their properties upon contact with various cell sorts and additionally extracellular lattice (Fejer and Gyory 2015). Macrophages are strikingly flexible in their capacity to perceive and react to an extensive variety of stimuli, communicating an assortment of surface and intracellular receptors, different sign transduction pathways and varieties of quality expression (Davies et al. 2013). Their inherent heterogeneity amid separation is intensified by corresponding cooperations with neighbouring cells, including macrophages themselves, different microorganisms, sterile particulates and dissolvable mediators (Fejer et al. 2013). Macrophages control activation of lymphocyte as well as their proliferation; they are also responsible in activating B and T- lymphocytes. They are also known as antigen presenting cells or APCs, which present antigens to T- lymphocytes after digesting microbes (Fejer and Gyory 2015). Macrophage and monocytes both are secretory in nature and release monokines, complement proteins and factors such as interleukin-1, such cells are known as activated macrophages (Davies et al. 2013). Macrophages also aid in muscle cell regeneration by two major groups. When the muscle tissue is damaged considerably, an influx of these phagocytic cells occur, which demolish and degrade the injured muscle fibres. A second group of macrophages, which are not phagocytic in nature, enables regeneration of muscle fibres (Yona et al. 2013). Type of macrophage Heterogeneity Macrophages are classified under mononuclear phagocyte system, which includes the phagocytic cells of the reticulo-endothelial system. The mononuclear phagocyte system is a major constituent of cell-mediated and humoral immunity. Interactions between pathogen and macrophages were studied using mice model, because of the accessibility of inbred strains. These studies gave a clear understanding of irresistible infections and the atomic system behind it (Davies et al. 2013). Self renewing macrophage system There are self renewing macrophage system under homeostatic condition include self renewal of tissue resident macrophages and self renewing macrophages during inflammation (Fejer et al. 2015). Refer to Appendix for figure. Heterogeneity of macrophages The macrophages are developed from monocytes circulating within the blood stream and display a very high level of heterogeneity, which has been revealed through extensive studies with monoclonal antibodies (Locati and Sica 2012). Usually monocytes show Epelman et al. 2014diversification in morphology of nucleus, size and granularity. Tissue macrophages on the contrary exhibit heterogeneity based on functions that differ according to their occurrence. For example, the osteoclasts found in bone tissue are responsible for tissue remodelling of bones, and pattern recognition receptors in alveolar macrophages, which help in cleaning the lung tissue by removal of pathogens (Fejer and Gyory 2015). The heterogeneity of macrophages is also observed in the mononuclear phagocyte system. The macrophages develop from the haematopetic stem cells that are multi-potent in nature and are self-renewing (Locati and Sica 2012). Different cell types MPI cells are non transformed, self renewing, primary phagocytes which are GM-CSF dependent. They are portrayed as murine model of Alveolar Macrophages due to similar properties (Fejer et al. 2015). The MPI cell model system contains cell population that are multiclonal and heterogeneous (size, function and morphology) in nature. On the contrary in AMs, this framework gives unhindered measures of essential macrophages, appropriate for intensive biochemical examination (Locati and Sica 2012). MPI cells are different from bone marrow derived macrophages and dendrite cells. The latter two are widely used in macrophage studies. However, MPI cells produces more amount of TNF- and IL-6 upon stimulation with the TLR4-dependent LPS (Epelman et al. 2014). Hypothesis This research is conducted to characterize individual cell clones of MPI functionally, and to prepare a pure culture of these clones in order to potentially reduce heterogeneity which derives from polyclonality. Proper optimization of attachment to the substrate, composition of the basal media, source of serum and the addition of the factors, which promote the proliferation of the cell, is the key to successful cloning. Additionally this research also intends to examine the reactions of these cloned cells towards various pathogens, ligands derived from pathogens and cytokines. This can be brought about by diverse tissue culture techniques such as cloning of single cell, analysis of growth curve and ELISA. The conducted research hypothesizes that obtaining pure culture of macrophages is possible from polyclonal MPI cell line. Appendix The figure below illustrates the self-renewal of Embryonic macrophages in homeostatic conditions, from foetal liver and the yolk sac. They are driven by M-CSF or GM-CSF. Self-renewing is also possible in inflammatory macrophages of embryonic origin. (Source: Fejer et al. 2015) References Davies, L.C., Jenkins, S.J., Allen, J.E. and Taylor, P.R., 2013. Tissue-resident macrophages.Nature immunology,14(10), pp.986-995. Epelman, S., Lavine, K.J. and Randolph, G.J., 2014. Origin and functions of tissue macrophages.Immunity,41(1), pp.21-35. Fejer, G., Sharma, S. and Gyory, I., 2015. Self-renewing macrophagesA new line of enquiries in mononuclear phagocytes.Immunobiology,220(2), pp.169-174. Fejer, G., Wegner, M.D., Gyry, I., Cohen, I., Engelhard, P., Voronov, E., Manke, T., Ruzsics, Z., Dlken, L., da Costa, O.P. and Branzk, N., 2013. Nontransformed, GM-CSFdependent macrophage lines are a unique model to study tissue macrophage functions.Proceedings of the National Academy of Sciences,110(24), pp.E2191-E2198. Locati, M., Mantovani, A. and Sica, A., 2012. Macrophage activation and polarization as an adaptive component of innate immunity.Advances in immunology,120, pp.163-184. Yona, S., Kim, K.W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A. and Hume, D.A., 2013. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.Immunity,38(1), pp.79-91.

Sunday, December 1, 2019

Rasmussens Encephalitis Essays - Encephalitis, Immune System

Rasmussen's Encephalitis Keyur P. Biology...Science Rasmussen's Encephalitis The human immune system is an amazing system that is constantly on the alert protecting us from sicknesses. Thousands of white blood cells travel in our circulatory system destroying all foreign substances that could cause harm to our body or to any of the millions of processes going on inside. Now imagine a condition where this awesome system turns against the most complex organ in the human body, the brain. Deadly as it is, this condition is known as Rasmussen's encephalitis. The meaningful research on Rasmussen's encephalitis was begun (unintentionally) by Scott Rogers and Lorise Gahring, two neurologists, who were at the time measuring the distribution of glutamate receptors in the brain. Later on when more provocative information was found they enlisted the help of James McNamara and Ian Andrews, epilepsy experts at Duke University Medical Center. The details on Rasmussen's encephalitis were very bleak at the time when the men began their research. All that was known is that Rasmussen's encephalitis was a degenerative disease of the brain that caused seizures, hemiparesis, and dementia normally in the first ten years of life. The seizures that were caused by Rasmussen's encephalitis were unstoppable by normal anti-seizure drugs used conventionally. What the worst part of the disease was that the pathogenesis for it were not known and even worse was how it developed. The first clue was delivered when Rogers and Gahring were trying to register the distribution of the glutamate receptors using antibodies, that tag on to the receptor itself. The proteins that make up the glutamate receptors(GluR) are only found inside the blood brain barrier(BBB). Glutamate and a few related amino acids are the dominant form of excitatory neurotransmitter in the central nervous system of mammals. If one of these GluRs happens to wander into the actual bloodstream, that is outside the BBB, it would be considered an outsider and destroyed immediately. So if these GluRs were put into the normal blood stream then the immune system would produce antibodies which could then be used in the searching for the glutamate receptors. In order to test this theory the researchers injected the GluRs into the blood stream of a normal healthy rabbit hoping to produce good results. At this point the experiment took a dramatic turn, after receiving a few doses of the protein two of the three rabbits began to twitch, as though they were suffering the pain of an epileptic seizure. Now the help of McNamara and Andrews was enlisted. When McNamara and Andrews examined the brain tissue of the rabbits, they saw what seemed to be a familiar inflammatory pattern, clumps of immune cells all around blood vessels. This description exactly matched the description of persons suffering from Rasmussen's encephalitis, moreover something as this would never be found in a healthy brain. A healthy brain has its blood capillaries enclosed in the BBB membrane, so such a case as the one mentioned above would not be possible. As protective as the BBB is, it can be breached by something like a head injury. What was happening was that the antibodies which were out to get the GluR proteins were somehow finding a way into the brain and directing an attack towards all GluR receptor proteins in the brain itself. After some more examinations Rogers and McNamara decided that these attacks were the cause of the seizures that are often experienced by sufferers of Ramussen's encephalitis. Then if the case is of antibodies in the bloodstream, than sufferers of Ramussen's encephalitis should have them in their bloodstream and healthy normal peoples shouldn't. When this was actually tested the results were positive that Rasmussen sufferers did have these antibodies in their bloodstreams and healthy people did not. These were not only the right kind of antibodies but, the very antibodies that caused the seizures in people and rabbits. Thus when these antibodies were removed by plasma exchange(PEX) it caused a temporary relief from the seizures but soon the body starts making more antibodies of the type and the seizures start once again. After all the examinations two questions remained, why does the body mount an immune response against one of its own brain proteins, and